Cauza insuccesului majoritatii dietelor si regimurilor de slabit. The reason your diet is doomed before you even start? You carry the greediness gene

O gena care provoaca stari incontrolabile de lacomie alimentara in randul a milioane de cetateni britanici

Recent, cercetatorii britanici au descoperit o gena care provoaca stari incontrolabile de lacomie alimentara in randul a milioane de cetateni ai Regatului Unit. Pe baza acestei descoperiri, pentru prima oara in lumea stiintifica se acrediteaza ideea.

Ultimele cercetari efectuate de expertii din cadrul Universitatii Oxford in domenul genelor care provoaca lacomia la nivel psihic si obezitatea la nivel fizic, au demonstrat existenta unei gene problema, responsabila pentru tot raul. „Gena lacomiei”, cum a fost botezata in gluma de cercetatori, a primit numele stiintific de FTO, iar activarea ei da peste cap si cele mai drastice diete, gena buclucasa provocand accese serioase de lacomie.

„Pentru prima data am demonstrat importanta genei FTO in declansarea obezitatii. Urmatorii nosti pasi constau in descifrarea modului in care aceasta gena influenteaza creierul uman sau altereaza mesajele transmise acestuia de catre ceulele din stratul adiopos sau alte tesuturi. O hiperactivitate a genei FTO duce la cresterea in greutate datorata mancatului in exces. Acum lucram la dezvoltarea unor medicamente care sa reduca activitatea genei.

Cei care se incearca diete de slabit sunt, in primul rand, condamanti sa le rateze. Degeaba esti la dieta, daca gena FTO s-a activat: foamea la nivel psihic este atat de mare incat vei uita de toate dietele din lume. Studiile noastre pe soarecii cu gena activata, au demonstrat ca cu cat rozatoarele mancau mai mult, cu atat senzatia de foame era mai mare, in loc sa dispara, dupa cum ar fi fost normal”, declara profesorul Frances Ashcrof, unul dintre conducatorii studiului.

The reason your diet is doomed before you even start? You carry the greediness gene

Millions of Britons carry a ‘greediness gene’ that makes diets doomed to failure.Researchers have shown that a rogue gene linked to obesity makes us fat by boosting appetite.This deep-seated drive to eat could also explain why so many slimmers succumb to temptation, no matter how strong their initial resolve to lose weight.

It’s all in the genes: Britons are the fattest in Europe, with more than 70 per cent of men and women classed as overweight or obese

The breakthrough opens the door for drugs that take the edge off appetite, melting away ‘muffin tops’ and pruning pot bellies.With Britain battling the worst weight problem in Europe and just one obesity drug on the market, there is an urgent need for new weapons in the battle of the bulge.

The British researchers studied a gene called FTO, which, when it was discovered in 2007, was the first widespread genetic flaw to be linked to obesity.

Up to 14 per cent of Britons carry two rogue copies of the rogue DNA, increasing their risk of obesity by 70 per cent and diabetes by 50 per cent.

These people are on average almost half a stone heavier.The 49 per cent who have inherited just one flawed FTO gene are 30 per cent more likely to be obese than those with two normal copies of the gene and 25 per cent more likely to develop diabetes.Despite this, it wasn’t clear whether the gene causes obesity, or is simply tends to occur at the same time to something else that does.

Mice bred to have extra copies of the rogue gene were healthy but ate more and became heavier than normal rodents.

Researcher Chris Church said: ‘For the first time we have provided convincing proof that the FTO gene causes obesity.’The next step is to understand how it does this, for instance whether it increases appetite by influencing our brain or alters messages from our fat stores and other tissues.’Once we know how FTO causes obesity we have the potential to look at developing drugs to treat it.’The researchers believe that the flawed version of FTO is more active than the normal one and ‘turning it down’ could dampen appetite.Professor Frances Ashcroft, one of the research leaders, said: ‘This work makes us confident that FTO is an important gene that contributes to obesity.’Too much activity of this gene can lead to putting on weight by overeating.’We can now think about developing drugs that turn down the activity of the FTO gene as potential anti-obesity pills.’That’s a long way of and there’s no certainty of success but it’s an enticing prospect.’Roger Cox, of the MRC, said: ‘There is a real need for new therapies.’There are simple things like exercise and diet that people can do to address obesity but it can but quite difficult to impact on weight using these approaches.’There is the potential for a goodnew therapiesthat doesn’t have as many side-effects as others.’Two prescription-only diet ‘wonder drugs’ have been banned over safety fears in recent years, leaving just one, orlistat, on the market.The research, reported in the journal Nature Genetics, could also help explain why so many diets are doomed to failure.Professor Cox said: ‘In this study, the mice were eating more, which suggests a bigger drive for food intake.’So you’d have that desire to eat even if you were on a diet and that drive can be quite strong, so you’d probably overeat.’Previous research has shown that one in four Britons are trying to lose weight at any one time.But more than two-thirds pile the pounds straight back on – and most end up heavier than they did to start.

Britons are the fattest in Europe, with more than 70 per cent of men and women classed as overweight or obese, raising their risk of heart disease, cancer and diabetes, and costing the NHS £1billion a year.

The latest research, from Oxford University and the Medical Research Council, shows that FTO does make us fat.

Surse: DailyMail si Descopera.ro

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